receptors are expressed most densely in the central nervous system and are largely responsible for mediating the effects of cannabinoid binding in the brain.Endocannabinoids released by a depolarized neuron bind to CB receptors on pre-synaptic glutamatergic and GABAergic neurons, resulting in a respective decrease in either glutamate or GABA release.This inhibition grows more pronounced when considered with the effect of activated CB receptors to limit calcium entry into the cell, which does not occur through c AMP but by a direct G-protein-mediated inhibition.As presynaptic calcium entry is a requirement for vesicle release, this function will decrease the transmitter that enters the synapse upon release.Aptamers functionalized on the GIAN nanostructure through simple, but strong, π–π interactions entered the cells through a clathrin-dependent pathway, while unmodified GIANs mainly entered the cells through a caveolae-mediated endocytosis pathway.Thus, it can be concluded that the mechanism of cellular uptake in these graphene-isolated-Au-nanocrystal nanostructures is determined by the presence or absence of aptamer modification.Researchers will use PET imaging to determine how lithium acts on the transmitter serotonin to provide therapeutic benefit in patients with bipolar disease.Lithium has been used for more than two decades to treat bipolar disorder, primarily by preventing or lessening depressive episodes and preventing patients’ tendencies toward suicide.
These studies investigate the factors that regulate macrophage activation to induce or suppress disease.
Recent work, in collaboration with other New Zealand and international researchers, is aimed at identifying new therapeutic targets and drugs to treat multiple sclerosis.
A possible mechanism for protection from autoimmunity.
This protein ordinarily clears away serotonin at the “synapse” between the sending and receiving cells.
By blocking the transporter, this excess serotonin also can be taken up by the receiving cell.